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Archived from the original on 7 December 2020. ^ "LINE Indonesia Awards 2019: Ayo Pilih Mulai dari Musisi, Film, hingga Influencer Terfavoritmu".Archived from the original on 19 December 2020. ^ "Daftar Lengkap Pemenang AMI Awards 2019".^ "Daftar Lengkap Nominasi AMI Awards 2019".Archived from the original on 6 December 2020.
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In the theater, Yugo kissed Milea she ran away from the mall in rage and asked Yugo not to see her again. One day, Milea's parents advised her to guide Yugo around Bandung, including the impromptu movie watching. Seeing Yugo as a foreign man in the car, Dilan does not see this as a threat and thus continues, to the point where he is caught for being involved in an attack using his father's pistol, in which his father is in the military and has affiliations to the police. One night, Dilan was caught planning an attack in late night, and Milea threatened him that she will break up with him if he does not change. Milea's cousin Yugo comes home from Belgium, and started acting incestuous towards Milea. Even with that, she continued genuinely being romantic with him. These results indicated that OAd35 is a promising alternative oncolytic virus for OAd5.Milea, now engaged in a relationship with Dilan, now faces problems with Dilan being an aggressive motorbike gang of his school, in which he is now expelled from, as well as involved in other aggressive activities, i.e. OAd35 significantly suppressed growth of the subcutaneous CAR-positive and CAR-negative tumors following intratumoral administration. Anti-Ad5 serum significantly inhibited in vitro tumor cell lysis activities of OAd5, whereas OAd35 exhibited comparable levels of in vitro tumor cell lysis activities in the presence of anti-Ad5 and naive serum. OAd35 mediated efficient cell lysis activities at levels similar to OAd5 in CAR-positive tumor cells, while OAd35 showed higher levels of cell lysis activities than OAd5 in CAR-negative tumor cells. Moreover, 20% or fewer adults have neutralizing antibodies against Ad35. OAd35 recognizes CD46, which is ubiquitously expressed on almost all human cells and is often upregulated on malignant tumor cells, as an infection receptor. In this study, we developed a novel OAd fully composed of OAd35. In addition, at least 80% of adults have neutralizing antibodies against Ad5. However, expression of the primary infection receptor for Ad5, coxsackievirus-adenovirus receptor (CAR), often declines on malignant tumor cells, resulting in inefficient infection in CAR-negative tumor cells. Almost all oncolytic adenoviruses are composed of human adenovirus serotype 5 (Ad5) (OAd5). Oncolytic adenoviruses (OAds) are among the most promising oncolytic viruses.