Effective pore diffusivities, D e, were obtained by fitting the chromatography general rate model to breakthrough data. Equilibrium isotherms were found to be highly favorable, with equilibrium binding capacity for monoclonal and bispecific antibodies ranging from 47–100 mg/mL packed bed across all stationary phases tested. Process performance and product quality were also examined under realistic bioprocess conditions using clarified mammalian cell culture broth. A panel of nine proteins spanning a wide range of structures and biochemical properties was then used to assess equilibrium uptake, mass transport, dynamic binding capacity, and elution pH.
We first examine the morphological properties of the stationary phases using a variety of orthogonal techniques including electron microscopy, particle sizing, pressure-flow behavior, and isocratic pulse response. Please refer to the returns policy on your college kit order form for the college kit specific returns and refunds policy.We describe a comprehensive evaluation of 12 Protein A stationary phases for capture of biotherapeutics. This may affect the total amount credited to you. Dennis Williams is entitled to make a charge for damaged or missing items. No refunds will be made in respect of carriage charges levied on the original order. Will charge a £5.00 handling charge per order, or 10% of the value, whichever is greater. (This does not affect your statutory rights) Goods must be unused and in re-saleable condition. requests that goods should be returned in their original sealed packaging where possible, with labels in-tact. We do not collect goods.Īdvises you for your own protection to retain your proof of postage, as we cannot be held responsible for packages that are damaged or lost in transit. Please note that you will be responsible for the costs of returning the goods to us unless we delivered the item to you in error or the item is faulty. Non standard items such as furniture/special order items unfortunately cannot be cancelled.Īll returned items should be sent insured via recorded delivery to Dennis Williams, 9 Kingsmark, Freeway Euroway Trading Estate (west), Oakenshaw, Bradford, BD12 7HW. In the unlikely event that your product is faulty, we will happily exchange it within 30 days, provided that you have notified us in writing within 14 days of receipt of the goods. Additional carriage charges may apply if goods are redelivered. We are happy to exchange a product within 14 days of purchase as long as the product has not been used. Please do not contact us about delivery of your kit before this time. (provided that we have received your order 14 working days before the start of your course, excluding Bank Holidays). In any event, your kit will be delivered no later than 7 days before the start of your course. We will endeavor to deliver your kit as soon as possible. VAT carriage charge applied to your order. Where your kit is designated for delivery to your college on a specified date, if we receive your order less than 3 days prior to this date your kit will be delivered to your home address and a £5.00 ex. College Kit DeliveryĬollege kits will be sent to the delivery address that is provided when the order is placed, (unless otherwise stated in the 'Kit Details' section on the order forms). The Scottish Highlands and Northern Ireland are excluded from online orders, however you can call 0345 6809 657 and place your order over the phone with a delivery charge.įor any queries, you can Contact Us by clicking here.ĭuring a Bank Holiday, online orders placed during the weekend will be dispatched on the following working week day. We ship throughout England, Scotland and Wales. If an item is out of stock our Customer Service Team will contact your with an estimated delivery date or a suggested alternative. Our aim is to dispatch all orders within 24 hours, subject to stock availability. *This excludes college kits, furniture, equipment and other bulky items for which delivery will be quoted at the time of ordering.
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